Utilizing magnetic resonance techniques to study membrane interactions of amyloid peptides.
Biochem Soc Trans
; 49(3): 1457-1465, 2021 06 30.
Article
em En
| MEDLINE
| ID: mdl-34156433
ABSTRACT
Alzheimer's disease (AD) is a common neurodegenerative condition that involves the extracellular accumulation of amyloid plaques predominantly consisting of Aß peptide aggregates. The amyloid plaques and soluble oligomeric species of Aß are believed to be the major cause of synaptic dysfunction in AD brain and their cytotoxic mechanisms have been proposed to involve interactions with cell membranes. In this review, we discuss our solid-state nuclear magnetic resonance (ssNMR) studies of Aß interactions with model membranes.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Espectroscopia de Ressonância Magnética
/
Membrana Celular
/
Peptídeos beta-Amiloides
/
Precursor de Proteína beta-Amiloide
/
Doença de Alzheimer
Limite:
Humans
Idioma:
En
Revista:
Biochem Soc Trans
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Austrália