Your browser doesn't support javascript.
loading
The roles of macrophage polarization in the host immune response to sepsis.
Chen, Xinsen; Liu, Yancun; Gao, Yulei; Shou, Songtao; Chai, Yanfen.
Afiliação
  • Chen X; Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, China.
  • Liu Y; Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, China.
  • Gao Y; Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, China.
  • Shou S; Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, China.
  • Chai Y; Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, China. Electronic address: chaiyanfen2012@126.com.
Int Immunopharmacol ; 96: 107791, 2021 Jul.
Article em En | MEDLINE | ID: mdl-34162154
Sepsis is a life-threatening clinical syndrome caused by infection. Its pathogenesis is complex and entails coagulation dysfunction, inflammation, and immune disorders. Macrophages are important components of innate and adaptive immunity that are highly heterogeneous and plastic. They can polarize into a multi-dimensional spectrum of phenotypes with different functions relating to immune regulation in response to changes in the microenvironment of specific tissues. We reviewed studies that examined the role of macrophage polarization with a focus on the classical activated (M1-like) and alternative activated (M2-like) macrophages as the two main phenotypes involved in the host immune response to sepsis. A complex regulatory network is involved in the process of macrophage polarization, which is influenced by a variety of signaling molecules, transcription factors, epigenetic modifications, and metabolic reprogramming. M1-like macrophages release large quantities of pro-inflammatory mediators, while M2-like macrophages release large quantities of anti-inflammatory mediators. An imbalance between M1-like and M2-like macrophages induces the occurrence and development of sepsis. Therefore, targeted regulation of the process of macrophage polarization could be a useful approach to normalize the immune balance of the host, offering a new treatment modality for different stages of sepsis.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sepse / Macrófagos Limite: Animals / Humans Idioma: En Revista: Int Immunopharmacol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sepse / Macrófagos Limite: Animals / Humans Idioma: En Revista: Int Immunopharmacol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China