Heat-killed Propionibacterium acnes augment the protective effect of 28-kDa glutathione S-transferases antigen against Schistosoma mansoni infection.
Acta Trop
; 222: 106033, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-34224719
ABSTRACT
Sm28GST is one of the candidate antigens for Schistosoma mansoni vaccine. Already Sm28GST vaccine formulations have shown to be protective against S. mansoni infection. Currently, efforts have been put into finding an adjuvant to enhance the immunity induced by Sm28GST. In the present work, we investigated whether heat-killed Propionibacterium acnes can be served as a potential adjuvant for recombinant Sm28GST (rSm28GST) antigen. As the results showed, P. acnes successfully modulated the Th1 humoral immune response induced by rSm28GST. Stronger Th1 cytokines responses were also observed in mice immunized with P. acnes-adjuvanted rSm28GST. Immunization of mice with P. acnes-adjuvanted rSm28GST was able to reduce worm burden and hepatic egg burden by 54.20 and 73.61%. Reduced granuloma size and count, as well as improved liver histology, were seen in P. acnes-adjuvanted rSm28GST immunized mice. These data suggest that P. acnes may evoke a stronger rSm28GST-induced immune response, higher resistance to S. mansoni infection, and more profound protection against S. mansoni-induced liver damages.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Propionibacterium acnes
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Esquistossomose mansoni
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Vacinas
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Glutationa Transferase
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Antígenos de Helmintos
Limite:
Animals
Idioma:
En
Revista:
Acta Trop
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Taiwan