New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutations.

Cheng, Liangkai; Wang, Huihui; Li, Shehan; Liu, Zhongqiu; Wang, Caiyan

Cheng, Liangkai; Wang, Huihui; Li, Shehan; Liu, Zhongqiu; Wang, Caiyan.

Afiliação

Cheng L; GuangDong Second Traditional Chinese Medicine Hospital, Guangzhou 510006, China.
Wang H; Guangdong Key Laboratory for Translational Cancer Research of Chinese Medicine, Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of C
Li S; Guangdong Key Laboratory for Translational Cancer Research of Chinese Medicine, Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of C
Liu Z; Guangdong Key Laboratory for Translational Cancer Research of Chinese Medicine, Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of C
Wang C; Guangdong Key Laboratory for Translational Cancer Research of Chinese Medicine, Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of C

Life Sci ; 282: 119791, 2021 Oct 01.

Article em En | MEDLINE | ID: mdl-34229009

Assuntos

Proteína 1 Associada a ECH Semelhante a Kelch/metabolismo; Fator 2 Relacionado a NF-E2/metabolismo; Neoplasias/metabolismo; Animais; Células HEK293; Humanos; Proteína 1 Associada a ECH Semelhante a Kelch/química; Proteína 1 Associada a ECH Semelhante a Kelch/genética; Camundongos; Modelos Moleculares; Mutação; Fator 2 Relacionado a NF-E2/química; Fator 2 Relacionado a NF-E2/genética; Neoplasias/genética; Ligação Proteica; Mapas de Interação de Proteínas

Palavras-chave

Binding assay; Cancer; ETGE motif; Keap1-Nrf2; Mutation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator 2 Relacionado a NF-E2 / Proteína 1 Associada a ECH Semelhante a Kelch / Neoplasias Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Life Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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