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Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation.
Rubinstein, Linda; Schreurs, Ann-Sofie; Torres, Samantha M; Steczina, Sonette; Lowe, Moniece G; Kiffer, Frederico; Allen, Antiño R; Ronca, April E; Sowa, Marianne B; Globus, Ruth K; Tahimic, Candice G T.
Afiliação
  • Rubinstein L; Universities Space Research Association, Columbia, MD, USA.
  • Schreurs AS; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
  • Torres SM; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
  • Steczina S; KBR, Houston, TX, USA.
  • Lowe MG; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
  • Kiffer F; Blue Marble Space Institute of Science, Seattle, WA, 98154, USA.
  • Allen AR; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
  • Ronca AE; Blue Marble Space Institute of Science, Seattle, WA, 98154, USA.
  • Sowa MB; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
  • Globus RK; Blue Marble Space Institute of Science, Seattle, WA, 98154, USA.
  • Tahimic CGT; Division of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
NPJ Microgravity ; 7(1): 24, 2021 Jul 06.
Article em En | MEDLINE | ID: mdl-34230490
Isolation on Earth can alter physiology and signaling of organs systems, including the central nervous system. Although not in complete solitude, astronauts operate in an isolated environment during spaceflight. In this study, we determined the effects of isolation and simulated microgravity solely or combined, on the inflammatory cytokine milieu of the hippocampus. Adult female wild-type mice underwent simulated microgravity by hindlimb unloading for 30 days in single or social (paired) housing. In hippocampus, simulated microgravity and isolation each regulate a discrete repertoire of cytokines associated with inflammation. Their combined effects are not additive. A model for mitochondrial reactive oxygen species (ROS) quenching via targeted overexpression of the human catalase gene to the mitochondria (MCAT mice), are protected from isolation- and/or simulated microgravity-induced changes in cytokine expression. These findings suggest a key role for mitochondrial ROS signaling in neuroinflammatory responses to spaceflight and prolonged bedrest, isolation, and confinement on Earth.

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: NPJ Microgravity Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: NPJ Microgravity Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos