Optimization of 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acids as inhibitors of Keap1-Nrf2 protein-protein interaction to suppress neuroinflammation.

Abed, Dhulfiqar Ali; Lee, Sumi; Wen, Xia; Ali, Ahmed R; Mangipudy, Vaibhav; Aleksunes, Lauren M; Hu, Longqin

Abed, Dhulfiqar Ali; Lee, Sumi; Wen, Xia; Ali, Ahmed R; Mangipudy, Vaibhav; Aleksunes, Lauren M; Hu, Longqin.

Afiliação

Abed DA; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Lee S; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Wen X; Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Piscataway, NJ 08854, USA.
Ali AR; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Mangipudy V; Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Aleksunes LM; Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Piscataway, NJ 08854, USA; Rutgers Cancer Institute of New Jersey, New
Hu L; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA. Electronic address: LongHu@pharmacy.rutgers.edu.

Bioorg Med Chem ; 44: 116300, 2021 08 15.

Article em En | MEDLINE | ID: mdl-34252790

Assuntos

Acetatos/farmacologia; Proteína 1 Associada a ECH Semelhante a Kelch/antagonistas & inibidores; Fator 2 Relacionado a NF-E2/antagonistas & inibidores; Naftalenos/farmacologia; Doenças Neuroinflamatórias/tratamento farmacológico; Acetatos/síntese química; Acetatos/química; Relação Dose-Resposta a Droga; Humanos; Proteína 1 Associada a ECH Semelhante a Kelch/química; Proteína 1 Associada a ECH Semelhante a Kelch/metabolismo; Estrutura Molecular; Fator 2 Relacionado a NF-E2/química; Fator 2 Relacionado a NF-E2/metabolismo; Naftalenos/síntese química; Naftalenos/química; Doenças Neuroinflamatórias/metabolismo; Ligação Proteica; Relação Estrutura-Atividade

Palavras-chave

Keap1; Keap1-Nrf2 interaction; Neuroinflammation; Nrf2; Oxidative stress; Protein-protein interaction inhibitor; Structure-activity relationship

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator 2 Relacionado a NF-E2 / Proteína 1 Associada a ECH Semelhante a Kelch / Doenças Neuroinflamatórias / Acetatos / Naftalenos Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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