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Selective Inhibition of the Second Bromodomain of BET Family Proteins Results in Robust Antitumor Activity in Preclinical Models of Acute Myeloid Leukemia.
Zhang, Lu; Cai, Tianyu; Lin, Xiaoyu; Huang, Xiaoli; Bui, Mai H; Plotnik, Joshua P; Bellin, Richard J; Faivre, Emily J; Kuruvilla, Vinitha M; Lam, Lloyd T; Lu, Xin; Zha, Zheng; Feng, Weiguo; Hessler, Paul; Uziel, Tamar; Zhang, Qi; Cavazos, Antonio; Han, Lina; Ferguson, Debra C; Mehta, Gaurav; Shanmugavelandy, Sriram S; Magoc, Terrance J; Rowe, Jenny; Goodwin, Neal C; Dorritie, Kathleen A; Boyiadzis, Michael; Albert, Daniel H; McDaniel, Keith F; Kati, Warren M; Konopleva, Marina; Shen, Yu.
Afiliação
  • Zhang L; Oncology Discovery, AbbVie Inc., North Chicago, Illinois.
  • Cai T; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Lin X; Oncology Discovery, AbbVie Inc., North Chicago, Illinois.
  • Huang X; Oncology Discovery, AbbVie Inc., North Chicago, Illinois.
  • Bui MH; Oncology Discovery, AbbVie Inc., North Chicago, Illinois.
  • Plotnik JP; Oncology Discovery, AbbVie Inc., North Chicago, Illinois.
  • Bellin RJ; Oncology Discovery, AbbVie Inc., North Chicago, Illinois.
  • Faivre EJ; Oncology Discovery, AbbVie Inc., North Chicago, Illinois.
  • Kuruvilla VM; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Lam LT; Oncology Discovery, AbbVie Inc., North Chicago, Illinois.
  • Lu X; Genomic Research Center, AbbVie Inc., North Chicago, Illinois.
  • Zha Z; Cyteir Therapeutics, 128 Spring Street, Lexington, Massachusetts.
  • Feng W; Genomic Research Center, AbbVie Inc., North Chicago, Illinois.
  • Hessler P; 190 Lisk Drive, Hainesville, Illinois.
  • Uziel T; Oncology Discovery, AbbVie Inc., North Chicago, Illinois.
  • Zhang Q; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Cavazos A; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Han L; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Ferguson DC; Oncology Discovery, AbbVie Inc., North Chicago, Illinois.
  • Mehta G; Oncology Discovery, AbbVie Inc., North Chicago, Illinois.
  • Shanmugavelandy SS; Oncology Discovery, AbbVie Inc., North Chicago, Illinois.
  • Magoc TJ; Cyteir Therapeutics, 128 Spring Street, Lexington, Massachusetts.
  • Rowe J; Charles River Laboratories, Wilmington, Massachusetts.
  • Goodwin NC; Champions Oncology, Rockville, Maryland.
  • Dorritie KA; Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • Boyiadzis M; Division of Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania.
  • Albert DH; Oncology Discovery, AbbVie Inc., North Chicago, Illinois.
  • McDaniel KF; Oncology Discovery, AbbVie Inc., North Chicago, Illinois.
  • Kati WM; Oncology Discovery, AbbVie Inc., North Chicago, Illinois.
  • Konopleva M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas. yu.shen@abbvie.com mkonople@mdanderson.org.
  • Shen Y; Oncology Discovery, AbbVie Inc., North Chicago, Illinois. yu.shen@abbvie.com mkonople@mdanderson.org.
Mol Cancer Ther ; 20(10): 1809-1819, 2021 10.
Article em En | MEDLINE | ID: mdl-34253595
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Pirróis / Sulfonamidas / Leucemia Mieloide Aguda / Proteínas / Compostos Bicíclicos Heterocíclicos com Pontes / Proteínas Proto-Oncogênicas c-bcl-2 Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Mol Cancer Ther Assunto da revista: ANTINEOPLASICOS Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Pirróis / Sulfonamidas / Leucemia Mieloide Aguda / Proteínas / Compostos Bicíclicos Heterocíclicos com Pontes / Proteínas Proto-Oncogênicas c-bcl-2 Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Mol Cancer Ther Assunto da revista: ANTINEOPLASICOS Ano de publicação: 2021 Tipo de documento: Article