Improved Genome Packaging Efficiency of Adeno-associated Virus Vectors Using Rep Hybrids.

Mietzsch, Mario; Eddington, Courtnee; Jose, Ariana; Hsi, Jane; Chipman, Paul; Henley, Tom; Choudhry, Modassir; McKenna, Robert; Agbandje-McKenna, Mavis

Mietzsch, Mario; Eddington, Courtnee; Jose, Ariana; Hsi, Jane; Chipman, Paul; Henley, Tom; Choudhry, Modassir; McKenna, Robert; Agbandje-McKenna, Mavis.

Afiliação

Mietzsch M; Department of Biochemistry and Molecular Biology, Center for Structural Biology, McKnight Brain Institute, College of Medicine, University of Floridagrid.15276.37, Gainesville, Florida, USA.
Eddington C; Department of Biochemistry and Molecular Biology, Center for Structural Biology, McKnight Brain Institute, College of Medicine, University of Floridagrid.15276.37, Gainesville, Florida, USA.
Jose A; Department of Biochemistry and Molecular Biology, Center for Structural Biology, McKnight Brain Institute, College of Medicine, University of Floridagrid.15276.37, Gainesville, Florida, USA.
Hsi J; Department of Biochemistry and Molecular Biology, Center for Structural Biology, McKnight Brain Institute, College of Medicine, University of Floridagrid.15276.37, Gainesville, Florida, USA.
Chipman P; Department of Biochemistry and Molecular Biology, Center for Structural Biology, McKnight Brain Institute, College of Medicine, University of Floridagrid.15276.37, Gainesville, Florida, USA.
Henley T; Intima Bioscience, New York, New York, USA.
Choudhry M; Intima Bioscience, New York, New York, USA.
McKenna R; Department of Biochemistry and Molecular Biology, Center for Structural Biology, McKnight Brain Institute, College of Medicine, University of Floridagrid.15276.37, Gainesville, Florida, USA.
Agbandje-McKenna M; Department of Biochemistry and Molecular Biology, Center for Structural Biology, McKnight Brain Institute, College of Medicine, University of Floridagrid.15276.37, Gainesville, Florida, USA.

J Virol ; 95(19): e0077321, 2021 09 09.

Article em En | MEDLINE | ID: mdl-34287038

Assuntos

Proteínas do Capsídeo/genética; Dependovirus/genética; Genes Virais; Vetores Genéticos; Empacotamento do Genoma Viral; Proteínas Virais/genética; Capsídeo/metabolismo; Proteínas do Capsídeo/metabolismo; Proteínas de Ligação a DNA/genética; Dependovirus/metabolismo; Células HEK293; Humanos; Proteínas Recombinantes de Fusão

Palavras-chave

RNA splicing; Rep protein; adeno-associated virus; capsid; cryo-electron microscopy; empty and full capsids; genome; hybrid; packaging

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Virais / Dependovirus / Proteínas do Capsídeo / Genes Virais / Empacotamento do Genoma Viral / Vetores Genéticos Tipo de estudo: Guideline / Risk_factors_studies Limite: Humans Idioma: En Revista: J Virol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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