Synthetic Study toward Saccharomicin Based upon Asymmetric Metal Catalysis.
Org Lett
; 23(15): 5969-5972, 2021 08 06.
Article
em En
| MEDLINE
| ID: mdl-34292756
ABSTRACT
Here, we report a de novo metal-catalyzed approach toward the stereoselective glycosidic bond formation in saccharomicin. The signature step is highlighted by the Pd-catalyzed asymmetric coupling of ene-alkoxyallenes and highly functionalized alcohol substrates. The reaction showed high chemo-, regio-, and ligand-driven diastereoselectivity. In combination with the ring-closing metathesis and late-stage functionalization, this method led to highly efficient synthesis of saccharosamine-rhamnose and rhamnose-fucose fragments.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ramnose
/
Fucose
/
Hexosaminas
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2021
Tipo de documento:
Article