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Pituitary corticotroph tumour with adrenocortical cells: A distinct clinicopathologic entity with unique morphology and methylation profile.
Hickman, Richard A; Gionco, John T; Faust, Phyllis L; Miller, Michael L; Bruce, Jeffrey; Page-Wilson, Gabrielle; Rosenblum, Marc K; Asa, Sylvia L.
Afiliação
  • Hickman RA; Department of Pathology and Cell Biology, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.
  • Gionco JT; Department of Pathology and Cell Biology, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.
  • Faust PL; Department of Pathology and Cell Biology, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.
  • Miller ML; Department of Pathology and Cell Biology, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.
  • Bruce J; Department of Neurological Surgery, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.
  • Page-Wilson G; Department of Medicine, Columbia University Irving Medical Center and New York Presbyterian Hospital, New York, New York, USA.
  • Rosenblum MK; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Asa SL; Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Neuropathol Appl Neurobiol ; 48(2): e12754, 2022 02.
Article em En | MEDLINE | ID: mdl-34296770
ABSTRACT
We describe a rare TPIT-positive corticotroph PitNET that is admixed with SF1-positive adrenocortical cells. This dimorphous population of cells showed no colocalisation between TPIT and SF1 by immunofluorescence, and an adrenocortical choristoma was favoured. Methylation array analysis revealed a novel methylation profile in relation to other pituitary neoplasms.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hipófise / Neoplasias Hipofisárias / Metilação de DNA / Adenoma Hipofisário Secretor de ACT / Corticotrofos Limite: Adult / Humans / Male Idioma: En Revista: Neuropathol Appl Neurobiol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hipófise / Neoplasias Hipofisárias / Metilação de DNA / Adenoma Hipofisário Secretor de ACT / Corticotrofos Limite: Adult / Humans / Male Idioma: En Revista: Neuropathol Appl Neurobiol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos