Exploiting lipotoxicity for the treatment of liver cancer.
Br J Cancer
; 125(11): 1459-1461, 2021 11.
Article
em En
| MEDLINE
| ID: mdl-34302061
ABSTRACT
Metabolic alterations occur frequently in solid tumours, but metabolic cancer therapies are limited by the complexity and plasticity of metabolic networks. We could recently show that activation of the liver X receptor alpha (LXRα) and inhibition of a Raf-1-SCD1 protein complex induces an intracellular accumulation of saturated free fatty acids leading to lethal lipotoxicity in tumour cells and allows for an efficient treatment of liver carcinomas.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores X do Fígado
/
Neoplasias Hepáticas
Limite:
Humans
Idioma:
En
Revista:
Br J Cancer
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Alemanha