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Disruption of NIPBL/Scc2 in Cornelia de Lange Syndrome provokes cohesin genome-wide redistribution with an impact in the transcriptome.
Garcia, Patricia; Fernandez-Hernandez, Rita; Cuadrado, Ana; Coca, Ignacio; Gomez, Antonio; Maqueda, Maria; Latorre-Pellicer, Ana; Puisac, Beatriz; Ramos, Feliciano J; Sandoval, Juan; Esteller, Manel; Mosquera, Jose Luis; Rodriguez, Jairo; Pié, J; Losada, Ana; Queralt, Ethel.
Afiliação
  • Garcia P; Cell Cycle Group, Institut d'Investigacions Biomèdica de Bellvitge (IDIBELL), Av. Gran Via de L'Hospitalet 199-203, Barcelona, Spain. pgarciar@idibell.cat.
  • Fernandez-Hernandez R; Instituto de Biología Funcional y Genómica, CSIC/Universidad de Salamanca and Departamento de Microbiología y Genética, Universidad de Salamanca, Salamanca, Spain. pgarciar@idibell.cat.
  • Cuadrado A; Cell Cycle Group, Institut d'Investigacions Biomèdica de Bellvitge (IDIBELL), Av. Gran Via de L'Hospitalet 199-203, Barcelona, Spain.
  • Coca I; Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
  • Gomez A; Research and Development Department, qGenomics Laboratory, Esplugues de Llobregat, Spain.
  • Maqueda M; Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.
  • Latorre-Pellicer A; Grup de Recerca de Reumatologia, Parc Científic de Barcelona, Barcelona, Spain.
  • Puisac B; Bioinformatics Unit, Institut d'Investigacions Biomèdica de Bellvitge (IDIBELL), Av. Gran Via de L'Hospitalet 199-203, Barcelona, Spain.
  • Ramos FJ; Unit of Clinical Genetics and Functional Genomics, Department of Pharmacology-Physiology and Paediatrics, School of Medicine, University of Zaragoza, CIBERER-GCV02 and IISAragon, Zaragoza, Spain.
  • Sandoval J; Unit of Clinical Genetics and Functional Genomics, Department of Pharmacology-Physiology and Paediatrics, School of Medicine, University of Zaragoza, CIBERER-GCV02 and IISAragon, Zaragoza, Spain.
  • Esteller M; Unit of Clinical Genetics and Functional Genomics, Department of Pharmacology-Physiology and Paediatrics, School of Medicine, University of Zaragoza, CIBERER-GCV02 and IISAragon, Zaragoza, Spain.
  • Mosquera JL; Biomarkers and Precision Medicine Unit (UByMP) and Epigenomics Core Facility, Health Research Institute La Fe (IISLaFe), Valencia, Spain.
  • Rodriguez J; Josep Carreras Leukaemia Research Institute (IJC), Barcelona, Catalonia, Spain.
  • Pié J; Centro de Investigación Biomédica en Red Cáncer (CIBERONC), Madrid, Spain.
  • Losada A; Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.
  • Queralt E; Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona, Barcelona, Catalonia, Spain.
Nat Commun ; 12(1): 4551, 2021 07 27.
Article em En | MEDLINE | ID: mdl-34315879
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Cromossômicas não Histona / Genoma Humano / Proteínas de Ciclo Celular / Síndrome de Cornélia de Lange / Transcriptoma Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Espanha
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Cromossômicas não Histona / Genoma Humano / Proteínas de Ciclo Celular / Síndrome de Cornélia de Lange / Transcriptoma Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Espanha