Anti-HIV activity of new pyrazolobenzothiazine 5,5-dioxide-based acetohydrazides.
Med Chem Res
; 24(10): 3671-3680, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-34316244
ABSTRACT
A series of fifteen new 2-[3-(3-chlorophenyl)-5,5-dioxidobenzo[e]pyrazolo[4,3-c][1,2]thiazin-4(2H)-yl]-N'-arylmethyleneacetohydrazides (5a-o) were synthesized and screened for their anti-HIV-1 and cytotoxicity activity. Out of fifteen pyrazolobenzothiazine-based hydrazones, thirteen were found to be active inhibitors of HIV with EC50 values <20 µM. Moreover, the cytotoxicity results showed that most of the compounds were toxic to PBM, CEM and Vero cell lines. This information could be used for structural modifications to acquire good candidates of HIV drugs.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Med Chem Res
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Paquistão