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A novel humanized model of rheumatoid arthritis associated lung disease.
Lin, Li; Xuan, Weixia; Luckey, David; Wang, Shaohua; Wang, FaPing; Lau, Jessica; Warrington, Kenneth J; Matteson, Eric L; Vassallo, Robert; Taneja, Veena.
Afiliação
  • Lin L; Division of Pulmonary and Critical Care Medicine, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States of America.
  • Xuan W; Division of Pulmonary and Critical Care Medicine, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States of America; Department of Resporatory medicine, Henan Provincial People's Hospital, Zhengzhou, China.
  • Luckey D; Department of Immunology, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States of America.
  • Wang S; Division of Pulmonary and Critical Care Medicine, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States of America.
  • Wang F; Division of Pulmonary and Critical Care Medicine, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States of America; Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.
  • Lau J; Division of Pulmonary and Critical Care Medicine, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States of America; Pulmonary and Critical Care Medicine, The Vancouver Clinic, Vancouver, WA, United States of America.
  • Warrington KJ; Division of Rheumatology, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States of America.
  • Matteson EL; Division of Rheumatology, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States of America.
  • Vassallo R; Division of Pulmonary and Critical Care Medicine, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States of America; Department of Medicine, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States of America. Electronic a
  • Taneja V; Department of Immunology, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States of America; Division of Rheumatology, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States of America. Electronic address: Taneja.Veena@m
Clin Immunol ; 230: 108813, 2021 09.
Article em En | MEDLINE | ID: mdl-34333094
Cigarette smoking has been implicated in the pathogenesis of seropositive rheumatoid arthritis (RA), as well as RA-associated lung disease. Fibrotic interstitial lung disease as well as emphysema occur in RA and cause substantial morbidity. We used arthritis-susceptible HLA-DQ8 transgenic mice to generate RA-associated lung disease. Mice were exposed to cigarette smoke (CS) prior to induction of arthritis, and subsequently injected with a low dose of bleomycin intra-tracheally to induce lung injury. Exposure of arthritic mice to both CS and bleomycin led to a significant reduction in lung compliance consistent with development of diffuse lung disease. Morphologic evaluation of the lung demonstrated areas of emphysematous change and co-existent fibrosis, consistent with a combined pattern of fibrosis and emphysema. These changes were accompanied by inflammatory cell infiltration and upregulation of fibrosis-associated genes. This humanized mouse model can serve as a valuable research tool to understand the pathogenesis of RA associated lung disease.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Doenças Pulmonares Intersticiais Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Clin Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Doenças Pulmonares Intersticiais Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Clin Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos