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TGFß2 and TGFß3 isoforms drive fibrotic disease pathogenesis.
Sun, Tianhe; Huang, Zhiyu; Liang, Wei-Ching; Yin, Jianping; Lin, Wei Yu; Wu, Jia; Vernes, Jean-Michel; Lutman, Jeff; Caplazi, Patrick; Jeet, Surinder; Wong, Tiffany; Wong, Manda; DePianto, Daryle J; Morshead, Katrina B; Sun, Kai-Hui; Modrusan, Zora; Vander Heiden, Jason A; Abbas, Alexander R; Zhang, Hua; Xu, Min; N'Diaye, Elsa-Noah; Roose-Girma, Meron; Wolters, Paul J; Yadav, Rajbharan; Sukumaran, Siddharth; Ghilardi, Nico; Corpuz, Racquel; Emson, Claire; Meng, Y Gloria; Ramalingam, Thirumalai R; Lupardus, Patrick; Brightbill, Hans D; Seshasayee, Dhaya; Wu, Yan; Arron, Joseph R.
Afiliação
  • Sun T; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. sun.tianhe@gene.com arron.joseph@gene.com.
  • Huang Z; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Liang WC; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Yin J; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lin WY; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Wu J; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Vernes JM; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lutman J; Department of Preclinical and Translational Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Caplazi P; Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Jeet S; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Wong T; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Wong M; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • DePianto DJ; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Morshead KB; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Sun KH; Department of Protein Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Modrusan Z; Department of Protein Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Vander Heiden JA; Department of OMNI Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Abbas AR; Department of OMNI Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Zhang H; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Xu M; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • N'Diaye EN; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Roose-Girma M; Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Wolters PJ; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Yadav R; Department of Preclinical and Translational Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Sukumaran S; Department of Preclinical and Translational Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Ghilardi N; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Corpuz R; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Emson C; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Meng YG; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Ramalingam TR; Department of Biomarker Discovery OMNI, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lupardus P; Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Brightbill HD; Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Seshasayee D; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Wu Y; Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Arron JR; Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. sun.tianhe@gene.com arron.joseph@gene.com.
Sci Transl Med ; 13(605)2021 08 04.
Article em En | MEDLINE | ID: mdl-34349032
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Crescimento Transformador beta2 / Fator de Crescimento Transformador beta3 Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Crescimento Transformador beta2 / Fator de Crescimento Transformador beta3 Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article