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A Wirelessly Controlled Smart Bandage with 3D-Printed Miniaturized Needle Arrays.
Derakhshandeh, Hossein; Aghabaglou, Fariba; McCarthy, Alec; Mostafavi, Azadeh; Wiseman, Chris; Bonick, Zack; Ghanavati, Ian; Harris, Seth; Kreikemeier-Bower, Craig; Basri, Seyed Masoud Moosavi; Rosenbohm, Jordan; Yang, Ruiguo; Mostafalu, Pooria; Orgill, Dennis; Tamayol, Ali.
Afiliação
  • Derakhshandeh H; Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
  • Aghabaglou F; Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
  • McCarthy A; Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
  • Mostafavi A; Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
  • Wiseman C; Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
  • Bonick Z; Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
  • Ghanavati I; Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
  • Harris S; Veterinary Diagnostic Center, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln Lincoln, NE 68583, USA.
  • Kreikemeier-Bower C; Institutional Animal Care Program, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
  • Basri SMM; Department of Biomedical Engineering, American University of Sharjah, Sharjah 26666, United Arab Emirates.
  • Rosenbohm J; Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
  • Yang R; Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
  • Mostafalu P; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02139, USA.
  • Orgill D; Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Tamayol A; Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE 68588, USA.
Adv Funct Mater ; 30(13)2020 Mar 24.
Article em En | MEDLINE | ID: mdl-34354556
ABSTRACT
Chronic wounds are one of the most devastating complications of diabetes and are the leading cause of nontraumatic limb amputation. Despite the progress in identifying factors and promising in vitro results for the treatment of chronic wounds, their clinical translation is limited. Given the range of disruptive processes necessary for wound healing, different pharmacological agents are needed at different stages of tissue regeneration. This requires the development of wearable devices that can deliver agents to critical layers of the wound bed in a minimally invasive fashion. Here, for the first time, a programmable platform is engineered that is capable of actively delivering a variety of drugs with independent temporal profiles through miniaturized needles into deeper layers of the wound bed. The delivery of vascular endothelial growth factor (VEGF) through the miniaturized needle arrays demonstrates that, in addition to the selection of suitable therapeutics, the delivery method and their spatial distribution within the wound bed is equally important. Administration of VEGF to chronic dermal wounds of diabetic mice using the programmable platform shows a significant increase in wound closure, re-epithelialization, angiogenesis, and hair growth when compared to standard topical delivery of therapeutics.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Adv Funct Mater Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Adv Funct Mater Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos