Benzalkonium chloride-induced myofibroblastic transdifferentiation of Tenon's capsule fibroblasts is inhibited by coculture with corneal epithelial cells or by interleukin-10.

Yamashiro, Chiemi; Tokuda, Kazuhiro; Kobayashi, Yuka; Higashijima, Fumiaki; Yoshimoto, Takuya; Ota, Manami; Ogata, Tadahiko; Ashimori, Atsushige; Kobayashi, Masaaki; Hatano, Makoto; Uchi, Sho-Hei; Wakuta, Makiko; Teranishi, Shinichiro; Kimura, Kazuhiro

Yamashiro, Chiemi; Tokuda, Kazuhiro; Kobayashi, Yuka; Higashijima, Fumiaki; Yoshimoto, Takuya; Ota, Manami; Ogata, Tadahiko; Ashimori, Atsushige; Kobayashi, Masaaki; Hatano, Makoto; Uchi, Sho-Hei; Wakuta, Makiko; Teranishi, Shinichiro; Kimura, Kazuhiro.

Afiliação

Yamashiro C; Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, 755-8505, Japan.
Tokuda K; Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, 755-8505, Japan.
Kobayashi Y; Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, 755-8505, Japan.
Higashijima F; Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, 755-8505, Japan.
Yoshimoto T; Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, 755-8505, Japan.
Ota M; Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, 755-8505, Japan.
Ogata T; Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, 755-8505, Japan.
Ashimori A; Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, 755-8505, Japan.
Kobayashi M; Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, 755-8505, Japan.
Hatano M; Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, 755-8505, Japan.
Uchi SH; Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, 755-8505, Japan.
Wakuta M; Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, 755-8505, Japan.
Teranishi S; Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, 755-8505, Japan.
Kimura K; Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, 755-8505, Japan. k.kimura@yamaguchi-u.ac.jp.

Sci Rep ; 11(1): 16096, 2021 08 09.

Article em En | MEDLINE | ID: mdl-34373467

Assuntos

Compostos de Benzalcônio/farmacologia; Transdiferenciação Celular/efeitos dos fármacos; Córnea/efeitos dos fármacos; Células Epiteliais/efeitos dos fármacos; Fibroblastos/efeitos dos fármacos; Interleucina-10/metabolismo; Miofibroblastos/efeitos dos fármacos; Cápsula de Tenon/efeitos dos fármacos; Actinas/metabolismo; Proliferação de Células/efeitos dos fármacos; Células Cultivadas; Técnicas de Cocultura/métodos; Córnea/metabolismo; Células Epiteliais/metabolismo; Fibroblastos/metabolismo; Fibrose/tratamento farmacológico; Fibrose/metabolismo; Humanos; Miofibroblastos/metabolismo; Transdução de Sinais/efeitos dos fármacos; Cápsula de Tenon/metabolismo; Transativadores/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Benzalcônio / Interleucina-10 / Córnea / Células Epiteliais / Transdiferenciação Celular / Cápsula de Tenon / Miofibroblastos / Fibroblastos Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão

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