Comparative study of different chiral ligands for dynamic kinetic resolution of amino acids.
Chirality
; 33(10): 685-702, 2021 10.
Article
em En
| MEDLINE
| ID: mdl-34402557
ABSTRACT
Dynamic kinetic resolution (DKR) of unprotected amino acids (AAs), via intermediate formation of Ni(II) complexes, is currently a leading methodology for preparation of natural and tailor-made AAs in enantiomerically pure form. In this work, we conduct a comparative case study of synthetic performance of four different ligands in DKR of six AAs representing aryl-, benzyl-, alkyl-, and long alkyl-type derivatives. The results of this study allow for rational selection of ligand/AA type to develop a practical procedure for preparation of target enantiomerically pure AAs.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aminoácidos
/
Níquel
Idioma:
En
Revista:
Chirality
Assunto da revista:
BIOLOGIA MOLECULAR
/
QUIMICA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Japão