Genome-Edited Coincidence and PMP22-HiBiT Fusion Reporter Cell Lines Enable an Artifact-Suppressive Quantitative High-Throughput Screening Strategy for <i>PMP22</i> Gene-Dosage Disorder Drug Discovery.

Martinez, Natalia J; Braisted, John C; Dranchak, Patricia K; Moran, John J; Larson, Hunter; Queme, Bryan; Pak, Evgenia; Dutra, Amalia; Rai, Ganesha; Cheng, Ken Chih-Chien; Svaren, John; Inglese, James

Genome-Edited Coincidence and PMP22-HiBiT Fusion Reporter Cell Lines Enable an Artifact-Suppressive Quantitative High-Throughput Screening Strategy for PMP22 Gene-Dosage Disorder Drug Discovery.

Martinez, Natalia J; Braisted, John C; Dranchak, Patricia K; Moran, John J; Larson, Hunter; Queme, Bryan; Pak, Evgenia; Dutra, Amalia; Rai, Ganesha; Cheng, Ken Chih-Chien; Svaren, John; Inglese, James.

Afiliação

Martinez NJ; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
Braisted JC; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
Dranchak PK; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
Moran JJ; Department of Comparative Biosciences, and Waisman Center, University of Wisconsin, Madison, Wisconsin 53705, United States.
Larson H; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
Queme B; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
Pak E; National Human Genome Research Institute, National Institute of Health, Bethesda, Maryland 20817, United States.
Dutra A; National Human Genome Research Institute, National Institute of Health, Bethesda, Maryland 20817, United States.
Rai G; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
Cheng KC; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.
Svaren J; Department of Comparative Biosciences, and Waisman Center, University of Wisconsin, Madison, Wisconsin 53705, United States.
Inglese J; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States.

ACS Pharmacol Transl Sci ; 4(4): 1422-1436, 2021 Aug 13.

Article em En | MEDLINE | ID: mdl-34423274

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Revista: ACS Pharmacol Transl Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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