Protective Effects of Flavonoids Against Mitochondriopathies and Associated Pathologies: Focus on the Predictive Approach and Personalized Prevention.
Int J Mol Sci
; 22(16)2021 Aug 11.
Article
em En
| MEDLINE
| ID: mdl-34445360
ABSTRACT
Multi-factorial mitochondrial damage exhibits a "vicious circle" that leads to a progression of mitochondrial dysfunction and multi-organ adverse effects. Mitochondrial impairments (mitochondriopathies) are associated with severe pathologies including but not restricted to cancers, cardiovascular diseases, and neurodegeneration. However, the type and level of cascading pathologies are highly individual. Consequently, patient stratification, risk assessment, and mitigating measures are instrumental for cost-effective individualized protection. Therefore, the paradigm shift from reactive to predictive, preventive, and personalized medicine (3PM) is unavoidable in advanced healthcare. Flavonoids demonstrate evident antioxidant and scavenging activity are of great therapeutic utility against mitochondrial damage and cascading pathologies. In the context of 3PM, this review focuses on preclinical and clinical research data evaluating the efficacy of flavonoids as a potent protector against mitochondriopathies and associated pathologies.
Palavras-chave
anti-oxidant activity; cancer; cardiovascular disease; dysfunction; flavonoids; genoprotection; injury; mitochondrial function; mitochondrial impairment; mitochondriopathy; natural substances; neurodegeneration; patient stratification; phytochemicals; predictive preventive personalized medicine (PPPM/3PM); stress; tumorigenesis
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
/
Doenças Mitocondriais
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Int J Mol Sci
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Eslováquia