Investigating how amine structure influences drug-amine ion-pair formation and uptake via the polyamine transporter in A549 lung cells.

Mohamed Sofian, Zarif; Harun, Norsyifa; Mahat, Mohd Muzamir; Nor Hashim, Nikman Adli; Jones, Stuart A

Mohamed Sofian, Zarif; Harun, Norsyifa; Mahat, Mohd Muzamir; Nor Hashim, Nikman Adli; Jones, Stuart A.

Afiliação

Mohamed Sofian Z; Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, 50603 Kuala Lumpur, Malaysia; Insitute of Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK. Electronic address:
Harun N; Centre for Drug Research, Universiti Sains Malaysia, 11800 Minden, Pulau Pinang, Malaysia.
Mahat MM; Faculty of Applied Sciences, Universiti Teknologi MARA, 40000 Shah Alam, Selangor, Malaysia.
Nor Hashim NA; Centre for Drug Research in Systems Biology, Structural Bioinformatics and Human Digital Imaging (CRYSTAL), Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Jones SA; Insitute of Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.

Eur J Pharm Biopharm ; 168: 53-61, 2021 Nov.

Article em En | MEDLINE | ID: mdl-34455038

Assuntos

Sistemas de Liberação de Medicamentos; Pulmão/metabolismo; Poliaminas/metabolismo; Teofilina/metabolismo; Células A549; Transporte Biológico; Humanos; Ligação de Hidrogênio; Pulmão/citologia; Poliaminas/química

Palavras-chave

Active uptake; Ion-pairing; Lung; Polyamines; Targeted delivery

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poliaminas / Teofilina / Sistemas de Liberação de Medicamentos / Pulmão Limite: Humans Idioma: En Revista: Eur J Pharm Biopharm Assunto da revista: FARMACIA / FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google