Ginsenoside 20(S)-Rh2 promotes cellular pharmacokinetics and intracellular antibacterial activity of levofloxacin against Staphylococcus aureus through drug efflux inhibition and subcellular stabilization.

Chen, Xiao-Yang; Qian, Fei; Wang, Yao-Yao; Liu, Yan; Sun, Yuan; Zha, Wei-Bin; Hao, Kun; Zhou, Fang; Wang, Guang-Ji; Zhang, Jing-Wei

Chen, Xiao-Yang; Qian, Fei; Wang, Yao-Yao; Liu, Yan; Sun, Yuan; Zha, Wei-Bin; Hao, Kun; Zhou, Fang; Wang, Guang-Ji; Zhang, Jing-Wei.

Afiliação

Chen XY; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
Qian F; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Wang YY; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
Liu Y; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
Sun Y; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
Zha WB; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
Hao K; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
Zhou F; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.
Wang GJ; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China. guangjiwang@hotmail.com.
Zhang JW; Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China. zhangjw_cnnj@sina.com.

Acta Pharmacol Sin ; 42(11): 1930-1941, 2021 11.

Article em En | MEDLINE | ID: mdl-34462563

Assuntos

Antibacterianos/farmacocinética; Ginsenosídeos/farmacocinética; Líquido Intracelular/metabolismo; Levofloxacino/farmacocinética; Staphylococcus aureus/metabolismo; Frações Subcelulares/metabolismo; Animais; Relação Dose-Resposta a Droga; Estabilidade de Medicamentos; Feminino; Humanos; Líquido Intracelular/efeitos dos fármacos; Masculino; Camundongos; Camundongos Endogâmicos ICR; Testes de Sensibilidade Microbiana/métodos; Staphylococcus aureus/efeitos dos fármacos; Frações Subcelulares/efeitos dos fármacos; Células THP-1

Palavras-chave

20(S)-Rh2; Staphylococcus aureus; cellular pharmacokinetics; drugdrug interaction; intracellular bacteria; levofloxacin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Staphylococcus aureus / Frações Subcelulares / Ginsenosídeos / Levofloxacino / Líquido Intracelular / Antibacterianos Limite: Animals / Female / Humans / Male Idioma: En Revista: Acta Pharmacol Sin Assunto da revista: FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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