Pooled analysis of recent studies of magnetic fields and childhood leukemia.
Environ Res
; 204(Pt A): 111993, 2022 03.
Article
em En
| MEDLINE
| ID: mdl-34481821
ABSTRACT
BACKGROUND:
Over forty epidemiologic studies have addressed an association between measured or calculated extremely-low-frequency magnetic fields (MF) and childhood leukemia. These studies have been aggregated in a series of pooled analyses, but it has been 10 years since the last such.METHODS:
We present a pooled analysis combining individual-level data (24,994 cases, 30,769 controls) from four recent studies on MF and childhood leukemia.RESULTS:
Unlike previous pooled analyses, we found no increased risk of leukemia among children exposed to greater MF odds ratio (OR) = 1.01, for exposure ≥0.4 µT (µT) compared with exposures <0.1 µT. Similarly, no association was observed in the subset of acute lymphoblastic leukemia, birth homes, studies using calculated fields, or when geocoding accuracy was ignored. In these studies, there is a decline in risk over time, also evident when we compare three pooled analyses. A meta-analysis of the three pooled analyses overall presents an OR of 1.45 (95% CI 0.95-2.20) for exposures ≥0.4 µT.CONCLUSIONS:
Our results are not in line with previous pooled analysis and show a decrease in effect to no association between MF and childhood leukemia. This could be due to methodological issues, random chance, or a true finding of disappearing effect.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Leucemia
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Child
/
Humans
Idioma:
En
Revista:
Environ Res
Ano de publicação:
2022
Tipo de documento:
Article