Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid modulate reductase activity.
Chem Commun (Camb)
; 57(72): 9068-9071, 2021 Sep 09.
Article
em En
| MEDLINE
| ID: mdl-34498652
ABSTRACT
Inspired by the boom of new artificial metalloenzymes, we developed an Fmoc-protected histidinium salt (Hum) as N-heterocyclic carbene precursor. Hum was placed via solid-phase peptide synthesis into short 7-mer peptides. Upon iridation, the metallo-peptidic construct displayed activity in catalytic hydrogenation that outperforms small molecule analogues and which is dependent on the peptide sequence, a typical feature of metalloenzymes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxirredutases
/
Peptídeos
/
Aminoácidos
/
Metano
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Suíça