Role of EphA4 in Mediating Motor Neuron Death in MND.
Int J Mol Sci
; 22(17)2021 Aug 30.
Article
em En
| MEDLINE
| ID: mdl-34502339
ABSTRACT
Motor neuron disease (MND) comprises a group of fatal neurodegenerative diseases with no effective cure. As progressive motor neuron cell death is one of pathological characteristics of MND, molecules which protect these cells are attractive therapeutic targets. Accumulating evidence indicates that EphA4 activation is involved in MND pathogenesis, and inhibition of EphA4 improves functional outcomes. However, the underlying mechanism of EphA4's function in MND is unclear. In this review, we first present results to demonstrate that EphA4 signalling acts directly on motor neurons to cause cell death. We then review the three most likely mechanisms underlying this effect.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença dos Neurônios Motores
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Morte Celular
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Receptor EphA4
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Neurônios Motores
Limite:
Animals
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Humans
Idioma:
En
Revista:
Int J Mol Sci
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Austrália