Micromechanical force promotes aortic valvular calcification.

Jiang, Yefan; Chen, Jinjie; Wei, Fuxiang; Wang, Yixuan; Chen, Si; Li, Geng; Dong, Nianguo

Jiang, Yefan; Chen, Jinjie; Wei, Fuxiang; Wang, Yixuan; Chen, Si; Li, Geng; Dong, Nianguo.

Afiliação

Jiang Y; Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Chen J; Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Wei F; Laboratory for Cellular Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Wang Y; Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Chen S; Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Li G; Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: ligeng@hust.edu.cn.
Dong N; Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: dongnianguo@hotmail.com.

J Thorac Cardiovasc Surg ; 164(6): e313-e329, 2022 12.

Article em En | MEDLINE | ID: mdl-34507817

Assuntos

Estenose da Valva Aórtica; Calcinose; Suínos; Animais; Valva Aórtica/metabolismo; Estenose da Valva Aórtica/etiologia; Estenose da Valva Aórtica/metabolismo; Calcinose/metabolismo; Subunidade alfa 1 de Fator de Ligação ao Core/genética; Subunidade alfa 1 de Fator de Ligação ao Core/metabolismo; Osteopontina/metabolismo; Integrina alfaVbeta3/metabolismo; Células Cultivadas

Palavras-chave

calcified aortic valvular disease; integrin αvß3; magnetic twisting cytometry; micromechanical force; valve interstitial cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estenose da Valva Aórtica / Calcinose Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: J Thorac Cardiovasc Surg Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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