Contraceptive and Infertility Target DataBase: a contraceptive drug development tool for targeting and analysis of human reproductive specific tissues.
Biol Reprod
; 105(6): 1366-1374, 2021 12 20.
Article
em En
| MEDLINE
| ID: mdl-34514504
ABSTRACT
The long and challenging drug development process begins with discovery biology for the selection of an appropriate target for a specific indication. Target is a broad term that can be applied to a range of biological entities such as proteins, genes, and ribonucleic acids (RNAs). Although there are numerous databases available for mining biological entities, publicly available searchable, downloadable databases to aid in target selection for a specific disease or indication (e.g., developing contraceptives and infertility treatments) are limited. We report the development of the Contraceptive and Infertility Target DataBase (https//www.citdbase.org), which provides investigators an interface to mine existing transcriptomic and proteomic resources to identify high-quality contraceptive/infertility targets. The development of similar databases is applicable to the identification of targets for other diseases and conditions.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reprodução
/
Anticoncepcionais
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Bases de Dados como Assunto
/
Desenvolvimento de Medicamentos
Limite:
Humans
Idioma:
En
Revista:
Biol Reprod
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos