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Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models.
Hotz, Christian; Wagenaar, Timothy R; Gieseke, Friederike; Bangari, Dinesh S; Callahan, Michelle; Cao, Hui; Diekmann, Jan; Diken, Mustafa; Grunwitz, Christian; Hebert, Andy; Hsu, Karl; Bernardo, Marie; Karikó, Katalin; Kreiter, Sebastian; Kuhn, Andreas N; Levit, Mikhail; Malkova, Natalia; Masciari, Serena; Pollard, Jack; Qu, Hui; Ryan, Sue; Selmi, Abderaouf; Schlereth, Julia; Singh, Kuldeep; Sun, Fangxian; Tillmann, Bodo; Tolstykh, Tatiana; Weber, William; Wicke, Lena; Witzel, Sonja; Yu, Qunyan; Zhang, Yu-An; Zheng, Gang; Lager, Joanne; Nabel, Gary J; Sahin, Ugur; Wiederschain, Dmitri.
Afiliação
  • Hotz C; BioNTech, 55131 Mainz, Germany.
  • Wagenaar TR; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Gieseke F; BioNTech, 55131 Mainz, Germany.
  • Bangari DS; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Callahan M; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Cao H; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Diekmann J; BioNTech, 55131 Mainz, Germany.
  • Diken M; BioNTech, 55131 Mainz, Germany.
  • Grunwitz C; Translational Oncology at the University Medical Center of Johannes Gutenberg University GmbH (TRON), 55131 Mainz, Germany.
  • Hebert A; BioNTech, 55131 Mainz, Germany.
  • Hsu K; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Bernardo M; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Karikó K; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Kreiter S; BioNTech, 55131 Mainz, Germany.
  • Kuhn AN; BioNTech, 55131 Mainz, Germany.
  • Levit M; Translational Oncology at the University Medical Center of Johannes Gutenberg University GmbH (TRON), 55131 Mainz, Germany.
  • Malkova N; BioNTech, 55131 Mainz, Germany.
  • Masciari S; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Pollard J; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Qu H; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Ryan S; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Selmi A; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Schlereth J; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Singh K; Translational Oncology at the University Medical Center of Johannes Gutenberg University GmbH (TRON), 55131 Mainz, Germany.
  • Sun F; BioNTech, 55131 Mainz, Germany.
  • Tillmann B; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Tolstykh T; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Weber W; Translational Oncology at the University Medical Center of Johannes Gutenberg University GmbH (TRON), 55131 Mainz, Germany.
  • Wicke L; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Witzel S; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Yu Q; BioNTech, 55131 Mainz, Germany.
  • Zhang YA; Translational Oncology at the University Medical Center of Johannes Gutenberg University GmbH (TRON), 55131 Mainz, Germany.
  • Zheng G; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Lager J; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Nabel GJ; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Sahin U; Research and Development, Sanofi, Cambridge, MA 02139, USA.
  • Wiederschain D; Research and Development, Sanofi, Cambridge, MA 02139, USA.
Sci Transl Med ; 13(610): eabc7804, 2021 Sep 08.
Article em En | MEDLINE | ID: mdl-34516826
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocinas / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocinas / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Sci Transl Med Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha