Beyond the Biosynthetic Gene Cluster Paradigm: Genome-Wide Coexpression Networks Connect Clustered and Unclustered Transcription Factors to Secondary Metabolic Pathways.

Kwon, Min Jin; Steiniger, Charlotte; Cairns, Timothy C; Wisecaver, Jennifer H; Lind, Abigail L; Pohl, Carsten; Regner, Carmen; Rokas, Antonis; Meyer, Vera

Kwon, Min Jin; Steiniger, Charlotte; Cairns, Timothy C; Wisecaver, Jennifer H; Lind, Abigail L; Pohl, Carsten; Regner, Carmen; Rokas, Antonis; Meyer, Vera.

Afiliação

Kwon MJ; Chair of Applied and Molecular Microbiology, Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany.
Steiniger C; Chair of Applied and Molecular Microbiology, Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany.
Cairns TC; Chair of Applied and Molecular Microbiology, Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany.
Wisecaver JH; Department of Biochemistry, Center for Plant Biology, Purdue University, West Lafayette, Indiana, USA.
Lind AL; Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA.
Pohl C; Gladstone Institute for Data Science and Biotechnology, San Francisco, California, USA.
Regner C; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Rokas A; Chair of Applied and Molecular Microbiology, Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany.
Meyer V; Chair of Applied and Molecular Microbiology, Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany.

Microbiol Spectr ; 9(2): e0089821, 2021 10 31.

Article em En | MEDLINE | ID: mdl-34523946

Assuntos

Aspergillus niger/genética; Aspergillus niger/metabolismo; Produtos Biológicos/metabolismo; Proteínas Fúngicas/genética; Metabolismo Secundário/genética; Descoberta de Drogas; Proteínas Fúngicas/metabolismo; Genoma Fúngico/genética; Redes e Vias Metabólicas/genética; Família Multigênica/genética; Fatores de Transcrição/genética

Palavras-chave

Aspergillus niger; correlation network; filamentous fungi; gene coexpression; gene regulation; genetic network; natural product; secondary metabolite gene clusters; specialized metabolism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aspergillus niger / Produtos Biológicos / Proteínas Fúngicas / Metabolismo Secundário Tipo de estudo: Prognostic_studies Idioma: En Revista: Microbiol Spectr Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha

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