Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks.
Nature
; 597(7877): 539-543, 2021 09.
Article
em En
| MEDLINE
| ID: mdl-34526718
ABSTRACT
Seven years after the declaration of the first epidemic of Ebola virus disease in Guinea, the country faced a new outbreak-between 14 February and 19 June 2021-near the epicentre of the previous epidemic1,2. Here we use next-generation sequencing to generate complete or near-complete genomes of Zaire ebolavirus from samples obtained from 12 different patients. These genomes form a well-supported phylogenetic cluster with genomes from the previous outbreak, which indicates that the new outbreak was not the result of a new spillover event from an animal reservoir. The 2021 lineage shows considerably lower divergence than would be expected during sustained human-to-human transmission, which suggests a persistent infection with reduced replication or a period of latency. The resurgence of Zaire ebolavirus from humans five years after the end of the previous outbreak of Ebola virus disease reinforces the need for long-term medical and social care for patients who survive the disease, to reduce the risk of re-emergence and to prevent further stigmatization.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Surtos de Doenças
/
Doença pelo Vírus Ebola
/
Ebolavirus
/
Modelos Biológicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
Nature
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Guiné