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Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy.
Anderson, Danielle E; Cui, Jin; Ye, Qian; Huang, Baoying; Tan, Ya; Jiang, Chao; Zu, Wenhong; Gong, Jing; Liu, Weiqiang; Kim, So Young; Yan, Biao Guo; Sigmundsson, Kristmundur; Lim, Xiao Fang; Ye, Fei; Niu, Peihua; Irving, Aaron T; Zhang, Haoyu; Tang, Yefeng; Zhou, Xuming; Wang, Yu; Tan, Wenjie; Wang, Lin-Fa; Tan, Xu.
Afiliação
  • Anderson DE; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, 169857 Singapore, Singapore.
  • Cui J; MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, 10008
  • Ye Q; MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, 10008
  • Huang B; National Health Commission Key Laboratory of Biosafety, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 102206 Beijing, China.
  • Tan Y; MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, 10008
  • Jiang C; MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, 10008
  • Zu W; MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, 10008
  • Gong J; MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, 10008
  • Liu W; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China.
  • Kim SY; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27708.
  • Yan BG; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, 169857 Singapore, Singapore.
  • Sigmundsson K; Programme in Cardiovascular & Metabolic Disorders, Duke-National University of Singapore Medical School, 169857 Singapore, Singapore.
  • Lim XF; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, 169857 Singapore, Singapore.
  • Ye F; National Health Commission Key Laboratory of Biosafety, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 102206 Beijing, China.
  • Niu P; National Health Commission Key Laboratory of Biosafety, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 102206 Beijing, China.
  • Irving AT; Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, 310058 Haining, China.
  • Zhang H; School of Pharmaceutical Sciences, Tsinghua University, 100084 Beijing, China.
  • Tang Y; School of Pharmaceutical Sciences, Tsinghua University, 100084 Beijing, China.
  • Zhou X; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China.
  • Wang Y; College of Life Sciences and Oceanography, Shenzhen University, 518071 Shenzhen, China.
  • Tan W; National Health Commission Key Laboratory of Biosafety, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 102206 Beijing, China.
  • Wang LF; Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, 169857 Singapore, Singapore; linfa.wang@duke-nus.edu.sg xutan@tsinghua.edu.cn.
  • Tan X; MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, 10008
Proc Natl Acad Sci U S A ; 118(39)2021 09 28.
Article em En | MEDLINE | ID: mdl-34544865
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pandemias / Formiato-Tetra-Hidrofolato Ligase / COVID-19 / Aminoidrolases / Metilenotetra-Hidrofolato Desidrogenase (NADP) / Complexos Multienzimáticos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Singapura
Texto completo
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pandemias / Formiato-Tetra-Hidrofolato Ligase / COVID-19 / Aminoidrolases / Metilenotetra-Hidrofolato Desidrogenase (NADP) / Complexos Multienzimáticos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Singapura