Dihydroergotamine affects spatial behavior and neurotransmission in the central nervous system of Wistar rats.
Ann Agric Environ Med
; 28(3): 437-445, 2021 Sep 16.
Article
em En
| MEDLINE
| ID: mdl-34558267
ABSTRACT
INTRODUCTION:
Dihydroergotamine (DHE) is a derivative of an ergot alkaloid used as an antimigraine medication. Nowadays, ergot alkaloids may still endanger the safety of humans and animals as food or medicine pollutants, but the outcomes of long-term DHE administration on the behaviour and neurotransmission remain undescribed. MATERIAL ANDMETHODS:
Adult male Wistar Albino Glaxo rats pre-treated orally with DHE for six weeks were investigated to assess the relationship between concentration of neurotransmitters and behavioural response. The behavioural effects of the drug administered at doses of either 30 µg/kg b.w. (group DHE30, n = 11) or 100 µg/kg b.w. per day (group DHE100, n = 10) were evaluated in the Morris Water Maze. It is known that monoaminergic neurotransmitters (serotonin, noradrenaline and dopamine) in some brain structures (prefrontal cortex, hippocampus, striatum, cerebellum, spinal cord) play a role in the control of cognitive and motor functions. The concentration of neurotransmitters was determined by High Performance Liquid Chromatography (HPLC).RESULTS:
Administration of DHE influenced neither the learning processes nor memory in rats. Nevertheless, an increased motor activity of the DHE-administered animals was observed in both the cued and non-cued behavioural tasks. In HPLC examination, changes in the concentration of monoaminergic neurotransmitters and their metabolites were noted in all tested structures, except for the hippocampus.CONCLUSIONS:
DHE is able to modulate noradrenergic, serotonergic and dopaminergic neurotransmission that may support the increase in locomotion.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Comportamento Espacial
/
Comportamento Animal
/
Di-Hidroergotamina
Limite:
Animals
Idioma:
En
Revista:
Ann Agric Environ Med
Assunto da revista:
SAUDE AMBIENTAL
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Polônia