TEA domain transcription factor 4 modulates repression of fetal haemoglobin by direct binding to the Î³-globin gene promoters.

Lin, Jiaqiong; Ye, Yuhua; Shang, Xuan; Zhang, Yanxia; Wei, Xiaofeng; Xu, Xiangmin

Lin, Jiaqiong; Ye, Yuhua; Shang, Xuan; Zhang, Yanxia; Wei, Xiaofeng; Xu, Xiangmin.

Afiliação

Lin J; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, China.
Ye Y; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, China.
Shang X; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, China.
Zhang Y; Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, China.
Wei X; Guangdong Genetics Testing Engineering Research Center, Guangzhou, Guangdong, China.
Xu X; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, China.

Br J Haematol ; 195(5): 764-769, 2021 12.

Article em En | MEDLINE | ID: mdl-34569056

Assuntos

Hemoglobina Fetal/genética; Regiões Promotoras Genéticas; Fatores de Transcrição de Domínio TEA/metabolismo; gama-Globinas/genética; Linhagem Celular; Células Eritroides/metabolismo; Regulação da Expressão Gênica; Humanos; Ligação Proteica; Talassemia beta/genética; Talassemia beta/metabolismo

Palavras-chave

CRISPR Cas9; TEA domain transcription factor 4; foetal haemoglobin; ß-thalassaemia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hemoglobina Fetal / Regiões Promotoras Genéticas / Gama-Globinas / Fatores de Transcrição de Domínio TEA Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Br J Haematol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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