Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment.
Int J Mol Sci
; 22(18)2021 Sep 16.
Article
em En
| MEDLINE
| ID: mdl-34576180
ABSTRACT
A variety of innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, natural killer cells, and neutrophils in the tumor microenvironments, contribute to tumor progression. However, while several recent reports have studied the use of immune checkpoint-based cancer immunotherapy, little work has focused on modulating the innate immune cells. This review focuses on the recent studies and challenges of using nanoparticles to target innate immune cells. In particular, we also examine the immunosuppressive properties of certain innate immune cells that limit clinical benefits. Understanding the cross-talk between tumors and innate immune cells could contribute to the development of strategies for manipulating the nanoparticles targeting tumor microenvironments.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Microambiente Tumoral
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Mol Sci
Ano de publicação:
2021
Tipo de documento:
Article