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Preclinical development of a bispecific TNFα/IL-23 neutralising domain antibody as a novel oral treatment for inflammatory bowel disease.
Roberts, Kevin J; Cubitt, Marion F; Carlton, Timothy M; Rodrigues-Duarte, Lurdes; Maggiore, Luana; Chai, Ray; Clare, Simon; Harcourt, Katherine; MacDonald, Thomas T; Ray, Keith P; Vossenkämper, Anna; West, Michael R; Crowe, J Scott.
Afiliação
  • Roberts KJ; VHsquared Ltd., 1 Lower Court, Copley Hill, Cambridge Road, Babraham, Cambridge, CB22 3GN, UK. KRoberts@sorrisopharma.com.
  • Cubitt MF; Sorriso Pharmaceuticals, Inc, 12230 El Camino Real, Suite 230, San Diego, CA, 92130, USA. KRoberts@sorrisopharma.com.
  • Carlton TM; VHsquared Ltd., 1 Lower Court, Copley Hill, Cambridge Road, Babraham, Cambridge, CB22 3GN, UK.
  • Rodrigues-Duarte L; Isogenica Ltd, The Mansion, Chesterford Research Park, Saffron Walden, CB10 1XL, UK.
  • Maggiore L; VHsquared Ltd., 1 Lower Court, Copley Hill, Cambridge Road, Babraham, Cambridge, CB22 3GN, UK.
  • Chai R; VHsquared Ltd., 1 Lower Court, Copley Hill, Cambridge Road, Babraham, Cambridge, CB22 3GN, UK.
  • Clare S; Isogenica Ltd, The Mansion, Chesterford Research Park, Saffron Walden, CB10 1XL, UK.
  • Harcourt K; VHsquared Ltd., 1 Lower Court, Copley Hill, Cambridge Road, Babraham, Cambridge, CB22 3GN, UK.
  • MacDonald TT; VHsquared Ltd., 1 Lower Court, Copley Hill, Cambridge Road, Babraham, Cambridge, CB22 3GN, UK.
  • Ray KP; Institute of Infection, Immunity and Inflammation, University of Glasgow, Sir Graeme Davies Building, 120 University Place, Glasgow, G12 8TA, UK.
  • Vossenkämper A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.
  • West MR; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge, CB2 0AW, UK.
  • Crowe JS; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.
Sci Rep ; 11(1): 19422, 2021 09 30.
Article em En | MEDLINE | ID: mdl-34593832
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Fator de Necrose Tumoral alfa / Anticorpos Biespecíficos / Avaliação Pré-Clínica de Medicamentos / Interleucina-23 / Anticorpos Monoclonais Limite: Animals / Female / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Fator de Necrose Tumoral alfa / Anticorpos Biespecíficos / Avaliação Pré-Clínica de Medicamentos / Interleucina-23 / Anticorpos Monoclonais Limite: Animals / Female / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido