LTA4H Prevalence and Mortality in Adult Zambians with Tuberculous Meningitis.
Ann Neurol
; 90(6): 994-998, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-34595756
ABSTRACT
We conducted a prospective cohort study to determine the prevalence of leukotriene A4 hydrolase (LTA4H) polymorphisms in Zambian adults with tuberculous meningitis (TBM) and its association with mortality. We completed genotype testing on 101 definite cases of TBM and 119 consecutive non-TBM controls. The distribution of genotypes among TBM patients was as follows C/C (0.83), C/T (0.14), T/T (0.03). There was no significant difference in genotype distribution between TBM and non-TBM patients. We found no relationship between LTA4H polymorphism and survival. Prospective studies are needed to determine the benefit of adjuvant steroids in TBM based upon population LTA4H genotype. ANN NEUROL 2021;90994-998.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tuberculose Meníngea
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Epóxido Hidrolases
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Genótipo
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Africa
Idioma:
En
Revista:
Ann Neurol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Marrocos