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LTA4H Prevalence and Mortality in Adult Zambians with Tuberculous Meningitis.
Siddiqi, Omar K; Ghebremichael, Musie; Musukuma, Kalo; Dang, Xin; Mubanga, Eugene; Birbeck, Gretchen L; Love, Shawn; Buback, Clayton; Kosloff, Barry; Ayles, Helen; Atadzhanov, Masharip; Koralnik, Igor J.
Afiliação
  • Siddiqi OK; Global Neurology Program, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA.
  • Ghebremichael M; Department of Internal Medicine, Center for Vaccines and Virology Research, Beth Israel Deaconess Medical Center, Boston, MA.
  • Musukuma K; Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia.
  • Dang X; Harvard Medical School and Ragon Institute of MGH, MIT, and Harvard, Boston, MA.
  • Mubanga E; Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia.
  • Birbeck GL; Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL.
  • Love S; Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia.
  • Buback C; Department of Neurology, University of Rochester, Rochester, NY.
  • Kosloff B; University Teaching Hospital, Neurology Research Office, Lusaka, Zambia.
  • Ayles H; Department of Neurology, University of California, Los Angeles, Los Angeles, CA.
  • Atadzhanov M; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Koralnik IJ; Zambart, Lusaka, Zambia.
Ann Neurol ; 90(6): 994-998, 2021 12.
Article em En | MEDLINE | ID: mdl-34595756
ABSTRACT
We conducted a prospective cohort study to determine the prevalence of leukotriene A4 hydrolase (LTA4H) polymorphisms in Zambian adults with tuberculous meningitis (TBM) and its association with mortality. We completed genotype testing on 101 definite cases of TBM and 119 consecutive non-TBM controls. The distribution of genotypes among TBM patients was as follows C/C (0.83), C/T (0.14), T/T (0.03). There was no significant difference in genotype distribution between TBM and non-TBM patients. We found no relationship between LTA4H polymorphism and survival. Prospective studies are needed to determine the benefit of adjuvant steroids in TBM based upon population LTA4H genotype. ANN NEUROL 2021;90994-998.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Meníngea / Epóxido Hidrolases / Genótipo Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Africa Idioma: En Revista: Ann Neurol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Marrocos
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Meníngea / Epóxido Hidrolases / Genótipo Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Africa Idioma: En Revista: Ann Neurol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Marrocos