Proteomics of colorectal cancer liver metastasis: A quantitative focus on drug elimination and pharmacodynamics effects.

Vasilogianni, Areti-Maria; Al-Majdoub, Zubida M; Achour, Brahim; Peters, Sheila Annie; Rostami-Hodjegan, Amin; Barber, Jill

Vasilogianni, Areti-Maria; Al-Majdoub, Zubida M; Achour, Brahim; Peters, Sheila Annie; Rostami-Hodjegan, Amin; Barber, Jill.

Afiliação

Vasilogianni AM; Centre for Applied Pharmacokinetic Research, School of Health Sciences, The University of Manchester, Manchester, UK.
Al-Majdoub ZM; Centre for Applied Pharmacokinetic Research, School of Health Sciences, The University of Manchester, Manchester, UK.
Achour B; Centre for Applied Pharmacokinetic Research, School of Health Sciences, The University of Manchester, Manchester, UK.
Peters SA; Translational Quantitative Pharmacology, Merck KGaA, Darmstadt, Germany.
Rostami-Hodjegan A; Centre for Applied Pharmacokinetic Research, School of Health Sciences, The University of Manchester, Manchester, UK.
Barber J; Certara Inc (Simcyp Division), Sheffield, UK.

Br J Clin Pharmacol ; 88(4): 1811-1823, 2022 02.

Article em En | MEDLINE | ID: mdl-34599518

Assuntos

Neoplasias Colorretais; Neoplasias Hepáticas; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/patologia; Vias de Eliminação de Fármacos; Humanos; Fígado/metabolismo; Neoplasias Hepáticas/tratamento farmacológico; Proteínas de Membrana Transportadoras/metabolismo; Proteômica/métodos

Palavras-chave

PBPK; QconCAT; colorectal cancer liver; drug-metabolizing enzymes; inflammation; metastasis; proteomics; receptor tyrosine kinases; transporters

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Neoplasias Hepáticas Limite: Humans Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google