Isolation of Group A Streptococci with Reduced In Vitro ß-Lactam Susceptibility Harboring Amino Acid Substitutions in Penicillin-Binding Proteins in Japan.
Antimicrob Agents Chemother
; 65(12): e0148221, 2021 11 17.
Article
em En
| MEDLINE
| ID: mdl-34606335
ABSTRACT
Streptococcus pyogenes (group A Streptococcus [GAS]) has long been regarded as being susceptible to ß-lactams. However, amino acid substitutions in penicillin-binding protein 2X (PBP2X) conferring reduced in vitro ß-lactam susceptibility have been indicated since 2019 in the United States and Iceland. Here, we report the first isolation of Streptococcus pyogenes possessing the PBP2X substitution conferring reduced in vitro ß-lactam susceptibility in Asia; however, the MICs were below the susceptible breakpoint of the CLSI.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Streptococcus pyogenes
/
Beta-Lactamas
País/Região como assunto:
Asia
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Japão