Fatty acids in normal and pathological pregnancies.
Mol Cell Endocrinol
; 539: 111466, 2022 01 01.
Article
em En
| MEDLINE
| ID: mdl-34610360
ABSTRACT
Long chain fatty acids, namely omega-3 and omega-6, are essential fatty acids and are necessary for proper pregnancy progression and fetal growth and development. Maternal fatty acid consumption and release of fatty acids from lipid stores provide increased availability of fatty acids for the placenta to transport to the growing fetus. Both omega-3 and omega-6 fatty acids are then utilized for generation of signaling molecules, such as eicosanoids, and for promoting of growth and developmental, most notably in the nervous system. Perturbations in fatty acid concentration and fatty acid signaling have been implicated in three major pregnancy complications - gestational diabetes, preeclampsia, and preterm birth. In this review we discuss the growing literature surrounding the role of fatty acids in normal and pathological pregnancies. Differences in maternal, placental, and fetal fatty acids and molecular regulation of fatty acid signaling and transport are presented. A look into novel fatty acid-based therapies for each of the highlighted disorders are discussed, and may present exciting bench to bedside alternatives to traditional pharmacological intervention.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Pré-Eclâmpsia
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Diabetes Gestacional
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Nascimento Prematuro
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Ácidos Graxos
Limite:
Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Revista:
Mol Cell Endocrinol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Estados Unidos