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Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam.
Fowler, Stephen; Brink, Andreas; Cleary, Yumi; Günther, Andreas; Heinig, Katja; Husser, Christophe; Kletzl, Heidemarie; Kratochwil, Nicole; Mueller, Lutz; Savage, Mark; Stillhart, Cordula; Tuerck, Dietrich; Ullah, Mohammed; Umehara, Kenichi; Poirier, Agnès.
Afiliação
  • Fowler S; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Brink A; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Cleary Y; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Günther A; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Heinig K; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Husser C; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Kletzl H; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Kratochwil N; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Mueller L; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Savage M; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Stillhart C; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Tuerck D; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Ullah M; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Umehara K; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
  • Poirier A; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel (S.F., A.B., Y.C., A.G., K.H., C.H., H.K, N.K., L.M., D.T., M.U., K.U., A.P.) and Formulation & Process Sciences, Pharmaceutical Research and Development (C.S.), F. Hoffmann-La Roche Ltd., Basel,
Drug Metab Dispos ; 50(1): 65-75, 2022 01.
Article em En | MEDLINE | ID: mdl-34620695
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Compostos Azo / RNA Mensageiro / Preparações Farmacêuticas / Distribuição Tecidual / Splicing de RNA Tipo de estudo: Guideline / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Compostos Azo / RNA Mensageiro / Preparações Farmacêuticas / Distribuição Tecidual / Splicing de RNA Tipo de estudo: Guideline / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Drug Metab Dispos Assunto da revista: FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article