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Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration.
Ambati, Meenakshi; Apicella, Ivana; Wang, Shao-Bin; Narendran, Siddharth; Leung, Hannah; Pereira, Felipe; Nagasaka, Yosuke; Huang, Peirong; Varshney, Akhil; Baker, Kirstie L; Marion, Kenneth M; Shadmehr, Mehrdad; Stains, Cliff I; Werner, Brian C; Sadda, Srinivas R; Taylor, Ethan W; Sutton, S Scott; Magagnoli, Joseph; Gelfand, Bradley D.
Afiliação
  • Ambati M; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22901.
  • Apicella I; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22908.
  • Wang SB; Center for Digital Image Evaluation, Charlottesville, VA 22901.
  • Narendran S; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22901.
  • Leung H; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22908.
  • Pereira F; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22901.
  • Nagasaka Y; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22908.
  • Huang P; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22901.
  • Varshney A; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22908.
  • Baker KL; Aravind Eye Hospital System, Madurai 625020, India.
  • Marion KM; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22901.
  • Shadmehr M; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22908.
  • Stains CI; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22901.
  • Werner BC; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22908.
  • Sadda SR; Departamento de Oftalmologia e Ciências Visuais, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil.
  • Taylor EW; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22901.
  • Sutton SS; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22908.
  • Magagnoli J; Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA 22901.
  • Gelfand BD; Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA 22908.
Proc Natl Acad Sci U S A ; 118(41)2021 10 12.
Article em En | MEDLINE | ID: mdl-34620711
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fluoxetina / Antidepressivos de Segunda Geração / Epitélio Pigmentado da Retina / Reposicionamento de Medicamentos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Degeneração Macular Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fluoxetina / Antidepressivos de Segunda Geração / Epitélio Pigmentado da Retina / Reposicionamento de Medicamentos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Degeneração Macular Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article