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CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression.
Schneider, Enja; Winzer, Riekje; Rissiek, Anne; Ricklefs, Isabell; Meyer-Schwesinger, Catherine; Ricklefs, Franz L; Bauche, Andreas; Behrends, Jochen; Reimer, Rudolph; Brenna, Santra; Wasielewski, Hauke; Lauten, Melchior; Rissiek, Björn; Puig, Berta; Cortesi, Filippo; Magnus, Tim; Fliegert, Ralf; Müller, Christa E; Gagliani, Nicola; Tolosa, Eva.
Afiliação
  • Schneider E; Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Winzer R; Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany. r.winzer@uke.de.
  • Rissiek A; Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Ricklefs I; Division of Pediatric Pneumology & Allergology, University Medical Center Schleswig-Holstein, 23538, Lübeck, Germany.
  • Meyer-Schwesinger C; Airway Research Center North, Member of the German Center for Lung Research, Lübeck, Germany.
  • Ricklefs FL; Department of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Bauche A; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Behrends J; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Reimer R; Core Facility Fluorescence Cytometry, Research Center Borstel, 23845, Borstel, Germany.
  • Brenna S; Technology Platform Microscopy and Image Analysis, Heinrich Pette Institute/Leibniz Institute for Experimental Virology, 20251, Hamburg, Germany.
  • Wasielewski H; Department of Neurology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Lauten M; Department of Immunology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Rissiek B; Department of Pediatrics and Adolescent Medicine, University of Lübeck, 23538, Lübeck, Germany.
  • Puig B; Department of Neurology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Cortesi F; Department of Neurology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Magnus T; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Fliegert R; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Müller CE; Department of Neurology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Gagliani N; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
  • Tolosa E; Department of Pharmaceutical & Medicinal Chemistry, University of Bonn, 53121, Bonn, Germany.
Nat Commun ; 12(1): 5911, 2021 10 08.
Article em En | MEDLINE | ID: mdl-34625545
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: 5'-Nucleotidase / Adenosina / Terapia de Imunossupressão / Linfócitos T CD8-Positivos / Proteínas Ligadas por GPI / Vesículas Extracelulares Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: 5'-Nucleotidase / Adenosina / Terapia de Imunossupressão / Linfócitos T CD8-Positivos / Proteínas Ligadas por GPI / Vesículas Extracelulares Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha