YTHDF2 is essential for spermatogenesis and fertility by mediating a wave of transcriptional transition in spermatogenic cells.

Zhao, Xinxi; Lin, Zhen; Fan, Yong; Li, Wenzhi; Zhang, Yujie; Li, Fei; Hong, Tong; Feng, Hua; Tong, Minghan; Wang, Ningling; Kuang, Yanping; Lyu, Qifeng

Zhao, Xinxi; Lin, Zhen; Fan, Yong; Li, Wenzhi; Zhang, Yujie; Li, Fei; Hong, Tong; Feng, Hua; Tong, Minghan; Wang, Ningling; Kuang, Yanping; Lyu, Qifeng.

Afiliação

Zhao X; Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.
Lin Z; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Fan Y; Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.
Li W; Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.
Zhang Y; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Li F; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Hong T; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Feng H; Omics Core, Bio-Med Big Data Center, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China.
Tong M; State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Wang N; Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.
Kuang Y; Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.
Lyu Q; Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.

Acta Biochim Biophys Sin (Shanghai) ; 53(12): 1702-1712, 2021 Dec 08.

Article em En | MEDLINE | ID: mdl-34664060

Assuntos

Fertilidade/genética; Células Germinativas/metabolismo; Proteínas de Ligação a RNA/genética; Proteínas de Ligação a RNA/metabolismo; Espermatogênese/genética; Animais; Apoptose/genética; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; RNA Mensageiro/metabolismo

Palavras-chave

YTHDF2 protein; infertility; m6A; oligospermia; spermatogenesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espermatogênese / Proteínas de Ligação a RNA / Fertilidade / Células Germinativas Limite: Animals Idioma: En Revista: Acta Biochim Biophys Sin (Shanghai) Assunto da revista: BIOFISICA / BIOQUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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