Read-across approaches: current applications and regulatory acceptance in Korea, Japan, and China.
J Toxicol Environ Health A
; 85(5): 184-197, 2022 03 04.
Article
em En
| MEDLINE
| ID: mdl-34670481
ABSTRACT
The aim of this paper was to investigate the current status of read-across approaches in the Republic of Korea, Japan, and China in terms of applications and regulatory acceptance. In the Republic of Korea, over the last 6 years, approximately 8% of safety data records used for chemical registrations were based upon read-across, and a guideline published on the use of read-across results in 2017. In Japan, read-across is generally accepted for screening hazard classification of toxicological endpoints according to the Chemical Substances Control Law (CSCL). In China, read-across data, along with data from other animal alternatives are accepted as a data source for chemical registrations, but could be only considered when testing is not technically feasible. At present, read-across is not widely used for chemical registrations and regulatory acceptance of read-across may differ among countries in Asia. With consideration of the advantages and limitations of read-across, it is expected that read-across may soon gradually be employed in Asian countries. Thus, regulatory agencies need to prepare for this progression.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Toxicologia
/
Substâncias Perigosas
/
Medição de Risco
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Toxicol Environ Health A
Assunto da revista:
SAUDE AMBIENTAL
/
TOXICOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article