Untangling the relationship between microglia and tau in Alzheimer's disease.
Trends Neurosci
; 44(12): 927-929, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-34674877
ABSTRACT
Autopsy and imaging studies have demonstrated a typical pattern of tau progression in Alzheimer's disease (AD), spreading to previously unaffected regions in an anatomical sequence of 'Braak' stages. In a recent study, Pascoal et al. provide evidence that microgliosis colocalizes with tau in a Braak-like pattern, furthering the notion that microglial activation is strongly related to the propagation of tangle pathology.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Microglia
/
Doença de Alzheimer
Limite:
Humans
Idioma:
En
Revista:
Trends Neurosci
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos