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Particle Beam Therapy Tolerance and Outcome on Patients with Autoimmune Diseases: A Single Institution Matched Case-Control Study.
Riva, Giulia; Vischioni, Barbara; Gandini, Sara; Cavalieri, Stefano; Ronchi, Sara; Barcellini, Amelia; Bonora, Maria; Chalaszczyk, Agnieszka; Ingargiola, Rossana; Vitolo, Viviana; Fiore, Maria Rosaria; Iannalfi, Alberto; Orlandi, Ester.
Afiliação
  • Riva G; Clinical Department, National Center for Oncological Hadrontherapy (CNAO), 27100 Pavia, Italy.
  • Vischioni B; Clinical Department, National Center for Oncological Hadrontherapy (CNAO), 27100 Pavia, Italy.
  • Gandini S; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, 20139 Milan, Italy.
  • Cavalieri S; Head and Neck Cancer Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.
  • Ronchi S; Clinical Department, National Center for Oncological Hadrontherapy (CNAO), 27100 Pavia, Italy.
  • Barcellini A; Clinical Department, National Center for Oncological Hadrontherapy (CNAO), 27100 Pavia, Italy.
  • Bonora M; Clinical Department, National Center for Oncological Hadrontherapy (CNAO), 27100 Pavia, Italy.
  • Chalaszczyk A; Clinical Department, National Center for Oncological Hadrontherapy (CNAO), 27100 Pavia, Italy.
  • Ingargiola R; Clinical Department, National Center for Oncological Hadrontherapy (CNAO), 27100 Pavia, Italy.
  • Vitolo V; Clinical Department, National Center for Oncological Hadrontherapy (CNAO), 27100 Pavia, Italy.
  • Fiore MR; Clinical Department, National Center for Oncological Hadrontherapy (CNAO), 27100 Pavia, Italy.
  • Iannalfi A; Clinical Department, National Center for Oncological Hadrontherapy (CNAO), 27100 Pavia, Italy.
  • Orlandi E; Clinical Department, National Center for Oncological Hadrontherapy (CNAO), 27100 Pavia, Italy.
Cancers (Basel) ; 13(20)2021 Oct 15.
Article em En | MEDLINE | ID: mdl-34680331
ABSTRACT
It is unclear whether autoimmune diseases (ADs) may predispose patients to higher radiation-induced toxicity, and no data are available regarding particle therapy. Our objective was to determine if cancer patients with ADs have a higher incidence of complications after protons (PT) or carbon ion (CIRT) therapy.

METHODS:

In our retrospective monocentric study, 38 patients with ADs over 1829 patients were treated with particle therapy between 2011 and 2020. Thirteen patients had collagen vascular disease (CVD), five an inflammatory bowel disease (IBD) and twenty patients an organ-specific AD. Each patient was matched with two control patients without ADs on the basis of type/site of cancer, type of particle treatment, age, sex, hypertension and/or diabetes and previous surgery.

RESULTS:

No G4-5 complications were reported. In the AD group, the frequency of acute grade 3 (G3) toxicity was higher than in the control group (15.8% vs. 2.6%, p = 0.016). Compared to their matched controls, CVD-IBD patients had a higher frequency of G3 acute complications (27.7 vs. 2.6%, p = 0.002). There was no difference between AD patients (7.9%) and controls (2.6%) experiencing late G3 toxicity (p = 0.33). The 2 years disease-free survival was lower in AD patients than in controls (74% vs. 91%, p = 0.01), although the differences in terms of survival were not significant.

CONCLUSIONS:

G3 acute toxicity was more frequently reported in AD patients after PT or CIRT. Since no severe G4-G5 events were reported and in consideration of the benefit of particle therapy for selected cancers, we conclude that particle therapy should be not discouraged for patients with ADs. Further prospective studies are warranted to gain insight into toxicity in cancer patients with ADs enrolled for particle therapy.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Revista: Cancers (Basel) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Revista: Cancers (Basel) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália