HLA alleles associated with asparaginase hypersensitivity in Chinese children.
J Hematol Oncol
; 14(1): 182, 2021 10 30.
Article
em En
| MEDLINE
| ID: mdl-34717720
ABSTRACT
Asparaginase is an important drug to treat childhood haematological malignancies. Data on the association between human leukocyte antigens (HLA) and asparaginase hypersensitivity among Chinese are lacking. We conducted a retrospective study to identify HLA alleles associated with asparaginase hypersensitivity among Chinese children with acute lymphoblastic leukaemia (ALL), mixed phenotype leukaemia and non-Hodgkin lymphoma (NHL), who received asparaginases with HLA typing performed between 2009 and 2019. 107 Chinese patients were analysed. 66.3% (71/107) developed hypersensitivity to at least one of the asparaginases. HLA-B*4601 (OR 3.8, 95% CI 1.4-10.1, p < 0.01) and DRB1*0901 (OR 4.3, 95% CI 1.6-11.4, p < 0.01) were significantly associated with L-asparaginase hypersensitivities, which remained significant after adjustment for age, gender and B cell ALL [HLA-B*4601 (adjusted OR 3.5, 95% 1.3-10.5, p = 0.02) and DRB1*0901 (OR 4.4, 95% CI 1.6-13.3, p < 0.01)].
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Asparaginase
/
Hipersensibilidade a Drogas
/
Antígenos HLA
/
Antineoplásicos
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Hematol Oncol
Assunto da revista:
HEMATOLOGIA
/
NEOPLASIAS
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China