Targeting alpha-synuclein via the immune system in Parkinson's disease: Current vaccine therapies.
Neuropharmacology
; 202: 108870, 2022 01 01.
Article
em En
| MEDLINE
| ID: mdl-34742741
ABSTRACT
Parkinson's disease (PD) is the second most common neurodegenerative disorder and is defined pathologically by the abnormal accumulation of the presynaptic protein alpha-synuclein (aSyn) in the form of Lewy bodies and Lewy neurites and loss of midbrain dopaminergic neurons in the substantia nigra pars compacta. Because of aSyn's involvement in both sporadic and familial forms of PD, it has become a key target for the development of novel therapeutics. Aberrant aSyn is associated with multiple mechanisms of neuronal dysfunction and degeneration including inflammation, impaired mitochondrial function, altered protein degradation systems, and oxidative stress. Inflammation, in particular, has emerged as a potential significant contributor early in the disease making it an attractive target for disease modification and neuroprotection. Thus, immunotherapies targeting aSyn are currently being investigated in pre-clinical and clinical trials. The focus of this review is to highlight the role of aSyn in neuroinflammation and discuss the current status of aSyn-directed immunotherapies in pre-clinical and clinical trials for PD.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
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Imunoterapia Ativa
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Alfa-Sinucleína
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Terapia de Alvo Molecular
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Sistema Imunitário
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Imunoterapia
Limite:
Animals
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Humans
Idioma:
En
Revista:
Neuropharmacology
Ano de publicação:
2022
Tipo de documento:
Article