MANF: A Novel Endoplasmic Reticulum Stress Response Protein-The Role in Neurological and Metabolic Disorders.
Oxid Med Cell Longev
; 2021: 6467679, 2021.
Article
em En
| MEDLINE
| ID: mdl-34745419
ABSTRACT
The mesencephalic astrocyte-derived neurotrophic factor (MANF), also named as arginine-rich protein (ARP) or arginine-rich mutated in early-stage tumors (ARMET), is a novel evolutionary conserved protein related to unfolded protein response. Growing evidence suggests that MANF critically involves in many ER stress-related diseases with a protective effect. Here, we review the function of MANF based on its structure in neurological and metabolic disorders and summarize its potential applications in disease diagnosis and therapies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Resposta a Proteínas não Dobradas
/
Estresse do Retículo Endoplasmático
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Doenças Metabólicas
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Fatores de Crescimento Neural
/
Doenças do Sistema Nervoso
Limite:
Humans
Idioma:
En
Revista:
Oxid Med Cell Longev
Assunto da revista:
METABOLISMO
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China