Are tyrosine kinase inhibitors an effective treatment in testicular metastases from kidney cancer? Case report.

Turco, Fabio; Tucci, Marcello; Di Stefano, Rosario Francesco; Samuelly, Alessandro; Bungaro, Maristella; Bollito, Enrico; Scagliotti, Giorgio Vittorio; Buttigliero, Consuelo

Turco, Fabio; Tucci, Marcello; Di Stefano, Rosario Francesco; Samuelly, Alessandro; Bungaro, Maristella; Bollito, Enrico; Scagliotti, Giorgio Vittorio; Buttigliero, Consuelo.

Afiliação

Turco F; Department of Oncology, University of Turin, at Division of Medical Oncology, San Luigi Gonzaga Hospital, Orbassano, Turin, Italy.
Tucci M; Medical Oncology Department, Cardinal Massaia Hospital, Asti, Italy.
Di Stefano RF; Department of Oncology, University of Turin, at Division of Medical Oncology, San Luigi Gonzaga Hospital, Orbassano, Turin, Italy.
Samuelly A; Department of Oncology, University of Turin, at Division of Medical Oncology, San Luigi Gonzaga Hospital, Orbassano, Turin, Italy.
Bungaro M; Department of Oncology, University of Turin, at Division of Medical Oncology, San Luigi Gonzaga Hospital, Orbassano, Turin, Italy.
Bollito E; Department of Pathology, University of Turin, at Division of Medical Oncology, San Luigi Gonzaga Hospital, Orbassano, Turin, Italy.
Scagliotti GV; Department of Oncology, University of Turin, at Division of Medical Oncology, San Luigi Gonzaga Hospital, Orbassano, Turin, Italy.
Buttigliero C; Department of Oncology, University of Turin, at Division of Medical Oncology, San Luigi Gonzaga Hospital, Orbassano, Turin, Italy.

Tumori ; 107(6): NP149-NP154, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34761706

RESUMO

Testicular metastases from renal cell carcinoma (RCC) are extremely rare. Tyrosine kinase inhibitors (TKI) are the cornerstone of systemic therapy for metastatic RCC. We report a case of testicular metastasis in a 72-year-old patient with RCC that developed 17 years after nephrectomy and response to TKI treatment, a retrospective literature search on testicular metastases from RCC, and the indirect evidence described in the literature on the efficacy of chemotherapy and target therapy on testicular lesions.

Assuntos

Neoplasias Renais/patologia; Terapia de Alvo Molecular; Inibidores de Proteínas Quinases/uso terapêutico; Neoplasias Testiculares/tratamento farmacológico; Neoplasias Testiculares/secundário; Idoso; Biomarcadores; Terapia Combinada; Gerenciamento Clínico; Humanos; Imuno-Histoquímica; Neoplasias Renais/diagnóstico; Neoplasias Renais/etiologia; Masculino; Inibidores de Proteínas Quinases/administração & dosagem; Inibidores de Proteínas Quinases/efeitos adversos; Avaliação de Sintomas; Neoplasias Testiculares/diagnóstico; Resultado do Tratamento

Palavras-chave

TKI; Testicular metastases; bloodtesticular barrier; cabozantinib; renal cell carcinoma; tyrosine kinase inhibitors

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Testiculares / Inibidores de Proteínas Quinases / Terapia de Alvo Molecular / Neoplasias Renais Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Aged / Humans / Male Idioma: En Revista: Tumori Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália

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